LIPIDYUM NEWS
23/09/2011
Buongiorno.
Ulteriori conferme sulla validità della combinazione
Fitosteroli-Fibra Viscosa (Lipidyum) derivano dagli articoli
seguenti.
Come si evince un "dietary portfolio", che miri alla riduzione della
colesterolemia, non include monacoline, berberina, policosanoli,
ecc, sostanze che "impegnano" vie metaboliche più "intime", di
pertinenza farmacologica più che nutrizionale (tra l'altro è in
corso una valutazione da parte di EFSA sul come classificare le
monacoline da riso rosso fermentato, se farmaco o integratore).
Ricordiamo che Lipidyum può essere associato alla statina, rispetto
alla quale vanta un'efficacia additiva, contribuendo al
raggiungimento dei desiderati target di colesterolemia.
Ricordiamo che Lipidyum esplica allo stesso tempo un'efficace e
fisiologica azione antistipsi.
Buon lavoro.
Marco Garimberti
ps: per richiedere saggi gratuiti, rispondere alla presente,
comunicando, se mutati, l'indirizzo di consegna merce.
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JAMA. 2011 Aug 24;306(8):831-9.
Effect of a dietary portfolio of cholesterol-lowering foods given at
2 levels of intensity of dietary advice on serum lipids in
hyperlipidemia: a randomized controlled trial.
Jenkins DJ, Jones PJ, Lamarche B, Kendall CW, Faulkner D, Cermakova
L, Gigleux I, Ramprasath V, de Souza R, Ireland C, Patel D,
Srichaikul K, Abdulnour S, Bashyam B, Collier C, Hoshizaki S, Josse
RG, Leiter LA, Connelly PW, Frohlich J.
Source
Clinical Nutrition and Risk Factor Modification Center, St Michael's
Hospital, 61 Queen St E, Toronto, ON M5C 2T2, Canada.
cyril.kendall@utoronto.ca
Abstract
CONTEXT:
Combining foods with recognized cholesterol-lowering properties
(dietary portfolio) has proven highly effective in lowering serum
cholesterol under metabolically controlled conditions.
OBJECTIVE:
To assess the effect of a dietary portfolio administered at 2 levels
of intensity on percentage change in low-density lipoprotein
cholesterol (LDL-C) among participants following self-selected
diets.
DESIGN, SETTING, AND PARTICIPANTS:
A parallel-design study of 351 participants with hyperlipidemia from
4 participating academic centers across Canada (Quebec City,
Toronto, Winnipeg, and Vancouver) randomized between June 25, 2007,
and February 19, 2009, to 1 of 3 treatments lasting 6 months.
INTERVENTION:
Participants received dietary advice for 6 months on either a
low-saturated fat therapeutic diet (control) or a dietary portfolio,
for which counseling was delivered at different frequencies, that
emphasized dietary incorporation of plant sterols, soy protein,
viscous fibers, and nuts. Routine dietary portfolio involved 2
clinic visits over 6 months and intensive dietary portfolio involved
7 clinic visits over 6 months.
MAIN OUTCOME MEASURES:
Percentage change in serum LDL-C.
RESULTS:
In the modified intention-to-treat analysis of 345 participants, the
overall attrition rate was not significantly different between
treatments (18% for intensive dietary portfolio, 23% for routine
dietary portfolio, and 26% for control; Fisher exact test, P = .33).
The LDL-C reductions from an overall mean of 171 mg/dL (95%
confidence interval [CI], 168-174 mg/dL) were -13.8% (95% CI, -17.2%
to -10.3%; P < .001) or -26 mg/dL (95% CI, -31 to -21 mg/dL; P <
.001) for the intensive dietary portfolio; -13.1% (95% CI, -16.7% to
-9.5%; P < .001) or -24 mg/dL (95% CI, -30 to -19 mg/dL; P < .001)
for the routine dietary portfolio; and -3.0% (95% CI, -6.1% to 0.1%;
P = .06) or -8 mg/dL (95% CI, -13 to -3 mg/dL; P = .002) for the
control diet. Percentage LDL-C reductions for each dietary portfolio
were significantly more than the control diet (P < .001,
respectively). The 2 dietary portfolio interventions did not differ
significantly (P = .66). Among participants randomized to one of the
dietary portfolio interventions, percentage reduction in LDL-C on
the dietary portfolio was associated with dietary adherence (r =
-0.34, n = 157, P < .001).
CONCLUSION: Use of a dietary portfolio compared with the
low-saturated fat dietary advice resulted in greater LDL-C lowering
during 6 months of follow-up.
TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00438425.
PMID: 21862744
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Circulation. 2011 Jul 18.
Combined Effects of Ezetimibe and Phytosterols on Cholesterol
Metabolism: A Randomized, Controlled Feeding Study in Humans.
Lin X, Racette SB, Lefevre M, Ma L, Spearie CA, Steger-May K,
Ostlund RE Jr.
Source: Division of Endocrinology, Metabolism, and Lipid Research,
Department of Medicine, Program in Physical Therapy, Center for
Applied Research Sciences, and Division of Biostatistics, Washington
University School of Medicine, St. Louis, MO, and Center for
Advanced Nutrition, Utah State University, Logan.
Abstract
Background- Both ezetimibe and phytosterols inhibit cholesterol
absorption. We tested the hypothesis that the combination of
ezetimibe and phytosterols is more effective than ezetimibe alone in
altering cholesterol metabolism. Methods and Results- Twenty-one
mildly hypercholesterolemic subjects completed a randomized,
double-blind, placebo-controlled, triple-crossover study. Each
subject received a phytosterol-controlled diet plus (1) ezetimibe
placebo+phytosterol placebo, (2) 10 mg/d ezetimibe+phytosterol
placebo, and (3) 10 mg/d ezetimibe+2.5 g phytosterols for 3 weeks
each. All meals were prepared in a metabolic kitchen. Primary
outcomes were intestinal cholesterol absorption, fecal cholesterol
excretion, and low-density lipoprotein cholesterol levels. The
combined treatment resulted in significantly lower intestinal
cholesterol absorption (598 mg/d; 95% confidence interval [CI], 368
to 828) relative to control (2161 mg/d; 95% CI, 1112 to 3209) and
ezetimibe alone (1054 mg/d; 95% CI, 546 to 1561; both P<0.0001).
Fecal cholesterol excretion was significantly greater (P<0.0001)
with combined treatment (962 mg/d; 95% CI, 757 to 1168) relative to
control (505 mg/d; 95% CI, 386 to 625) and ezetimibe alone (794
mg/d; 95% CI, 615 to 973). Plasma low-density lipoprotein
cholesterol values during treatment with control, ezetimibe alone,
and ezetimibe+phytosterols averaged 129 mg/dL (95% CI, 116 to 142),
108 mg/dL (95% CI, 97 to 119), and 101 mg/dL (95% CI, 90 to 112;
(P<0.0001 relative to control).
Conclusion- The addition of phytosterols to ezetimibe significantly
enhanced the effects of ezetimibe on whole-body cholesterol
metabolism and plasma low-density lipoprotein cholesterol. The large
cumulative action of combined dietary and pharmacological treatment
on cholesterol metabolism emphasizes the potential importance of
dietary phytosterols as adjunctive therapy for the treatment of
hypercholesterolemia. Clinical Trial Registration- URL:
http://www.clinicaltrials.gov. Unique identifier: NCT00863265.
---
22/01/2011
Riflessioni di rilevanza pratica sull'approccio NON farmacologico
alla dislipidemia.
Sono in linea con la composizione di
Lipidyum (fibra viscosa + fitosteroli); il
seguente Poster
attesta che i citati ingredienti attivi combinati NON
competono ma SINERGIZZANO dal punto di vista "Farmacodinamico",
sommando i rispettivi potenziali ipolipemizzanti.
Curr Opin Lipidol. 2011
Feb;22(1):43-8.
Lowering
LDL-cholesterol through diet: potential role in the statin era.
Department of
Endocrinology and Metabolism, Groupe Hospitalier Pitié-Salpêtrière,
Assistance Publique-Hôpitaux de Paris, Paris, France.
Abstract
Purpose of Review: A healthy diet should be rich
in vegetables and fruits, whole-grain, high-fiber foods, and fish and
should contain a small amount of saturated and trans fats. In addition
to these recommendations, some food ingredients such as plant
sterol/stanol soy protein and isoflavones may help reduce cholesterol
levels. Increased dietary fiber intakes are associated with
significantly lower prevalence of cardiovascular disease and lower
LDL-cholesterol concentration of about 5-10%. Beyond LDL-cholesterol
lowering effects, other benefits have been observed on hypertension,
diabetes mellitus. In this review, we summarize the different dietary
approaches proven to be associated with LDL-cholesterol decrease.
Nutritional interventions that do not exert significant LDL-cholesterol
decrease have not been included in this review.
RECENT FINDINGS:
On top of a 'classical' step 1 and step 2 diet, the cornerstone of
dietary recommendations, recent findings confirm the deleterious effects
of trans fatty acid or the beneficial effects of sterols/stanols and
nuts.
---
20/01/2011
combinazione fitosteroli - fibra viscosa apportata.
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10/01/2010
Inviamo alcuni abstract, che a nostro avviso confermano la validità di una supplementazione alimentare a base di Lipidyum in molte delle condizioni che giungono alla Vostra osservazione; Lipidyum combina infatti fitosteroli e psyllium (e inulina).
I risultati "fitosteroli nei bambini", di cui all'abstract a seguire, sono stati ottenuti grazie ad una mono somministrazione giornaliera di circa 2 g di fitosteroli non esteri.
Lipidyum è stato invece formulato per apportare lo stesso quantitativo di fitosteroli attraverso due assunzioni giornaliere, ognuna prima del pasto principale, così da indurre una favorevole azione sull'appetito, associata alla contemporanea assunzione di fibra viscosa.
Lipidyum = + fibra, + di una fibra, + della fibra, nella gestione della Persona dismetabolica e/o con rallentato transito intestinale.
Un saluto,
Marco Garimberti
-
Acta Diabetol. 2010 Nov 6.
Primary hyperlipidemias in children: effect of plant sterol
supplementation on plasma lipids and markers of cholesterol
synthesis and absorption.
Guardamagna O,
Abello F,
Baracco V,
Federici G,
Bertucci P,
Mozzi A,
Mannucci L,
Gnasso A,
Cortese C.
Department of Pediatrics, Turin University, Turin, Italy.
Abstract
Plant sterols lower serum cholesterol concentration. Available data
have confirmed the lipid-lowering efficacy in adults, while there is
a relative dearth of data in children and almost exclusively
restricted to subjects with familial hypercholesterolemia (FH). Aim
of the present study was to evaluate the efficacy,
tolerability and safety of plant sterol
supplementation in children with different forms of primary
hyperlipidemias. The effect of plant sterol consumption on
plasma lipids was evaluated in 32 children with heterozygous FH, 13
children with Familial Combined Hyperlipidemia (FCH) and 13 children
with Undefined Hypercholesterolemia (UH) in a 12-week open-label
intervention study using plant sterol-enriched yoghurt. Plasma
lipids and apolipoproteins were measured by routine methods. Markers
of cholesterol synthesis (lathosterol) and absorption (campesterol
and sitosterol) were measured by GC-MS. Tolerability and adherence
to recommended regimen was very high. A significant reduction was
observed in LDL-cholesterol in the three groups (10.7, 14.2 and
16.0% in FH, FCH and UH, respectively). Lathosterol concentrations
were unchanged, reflecting a lack of increased synthesis of
cholesterol. Of the two absorption markers, only sitosterol showed a
slight but significant increase. Daily consumption of plant sterol
dairy products favorably changes lipid profile by reducing
LDL-cholesterol. To our knowledge, this is the first report of the
use of plant sterols-enriched foods in treating children with
primary hyperlipidemia such as FCH and UH, likely to be the most
frequent form also in the young age in the western populations.
-
Appetite. 2010 Nov 27.
Dietary fibres in the regulation of appetite and food intake.
Importance of viscosity.
Kristensen M,
Jensen MG.
Department of Human Nutrition, University of Copenhagen,
Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark.
Abstract
Dietary fibres have many functions
in the diet, one of which may be to promote control of energy intake
and reduce the risk of developing obesity. This is linked to the
unique physico-chemical properties of dietary fibres which aid early
signalling of satiation and prolonged or enhanced sensation of
satiety. Particularly the ability of some dietary fibres to increase
viscosity of intestinal contents offers numerous opportunities to
affect appetite regulation. This may be linked to increased chyme
viscosity, as linseed dietary fibre has water holding capacity and
intrinsic viscosity which is comparable to that of psyllium and guar
gum. Few papers on the satiating effect of dietary fibres include
information on the physico-chemical characteristics of the dietary
fibres being tested, including molecular weight and viscosity. For
viscosity to serve as a proxy for soluble dietary fibres it is
essential to have an understanding of individual dietary fibre
viscosity characteristics. The goal of this paper is to provide a
brief overview on the role of dietary fibres in appetite regulation
highlighting the importance of viscosity and also include new
findings on the role of linseed dietary fibre on appetite
regulation.
-
Ann Pharmacother. 2010
Nov;44(11):1786-92. Epub 2010 Oct 19.
Effects of dietary fiber and low glycemic index diet on glucose
control in subjects with type 2 diabetes mellitus.
Bajorek SA,
Morello CM.
University of California, San Diego, La Jolla, USA.
Abstract
OBJECTIVE: To review
the effects of dietary fiber and a low glycemic index diet on
glycemic risk factors in people with type 2 diabetes mellitus (T2DM)
or T2DM and dyslipidemia.
DATA SOURCES:
Literature search was conducted using PubMed, Cochrane Library, The
Natural Standard, and The Natural Medicines through July 2010 using
the terms type 2 diabetes mellitus, dietary fiber, psyllium, and
glycemic index.
STUDY SELECTION AND DATA
EXTRACTION: Articles included were randomized
controlled studies or meta-analyses examining the effects of dietary
interventions (dietary fiber, low glycemic index diet, or psyllium)
on glycemic risk factors (glycosylated hemoglobin A₁(c) [A1C] or
postprandial plasma glucose [PPG] concentrations) in subjects with
T2DM or T2DM and dyslipidemia.
DATA SYNTHESIS:
Both psyllium supplementation and low glycemic index diets
have been studied as monotherapy in the treatment of T2DM. Seven
studies were reviewed (3 randomized crossover studies, 1 randomized
parallel study, 3 randomized blinded parallel studies).
Individually, psyllium supplementation and a low glycemic
index diet improved glycemic risk factors. PPG and A1C
decreased with psyllium 10.2 g per day, while A1C decreased with a
low glycemic index diet (average glycemic index 59). However, the
results for the low glycemic index diet are controversial. One study
was underpowered to detect changes in A1C, while another study had
psyllium fiber as a confounding variable.
CONCLUSIONS:
Psyllium supplementation might be an additional
therapeutic option for people with T2DM who are already receiving
diabetes medication and who still experience elevated PPG
concentrations. Further well-designed clinical trials and adjustment
for confounding variables are needed to determine the role of a low
glycemic index diet in the treatment of T2DM.
-
Br J Nutr. 2011
Jan;105(1):90-100. Epub 2010 Aug 23.
The effect of a fibre supplement compared to a healthy diet on body
composition, lipids, glucose, insulin and other metabolic syndrome
risk factors in overweight and obese individuals.
Pal S,
Khossousi A,
Binns C,
Dhaliwal S,
Ellis V.
School of Public Health, Curtin Health Innovation Research
Institute, ATN Centre for Metabolic Fitness, Curtin University of
Technology, GPO Box U1987, Perth, WA, Australia 6485.
Abstract
Optimum levels and types of dietary fibre that provide the greatest
beneficial effects on metabolic syndrome risk factors
in overweight and obese individuals have yet to be
determined in clinical trials. The present parallel design study
compared the effects of fibre intake from a healthy diet v. a fibre
supplement (psyllium) or a healthy diet plus fibre supplement on
fasting lipids, glucose, insulin and body composition.
Overweight/obese adults were randomised to either control (with
placebo), fibre supplement (FIB), healthy eating plus placebo (HLT)
or healthy eating plus fibre supplement (HLT-FIB). There was a
significant increase in fibre intake in HLT-FIB, HLT and FIB groups
up to 59, 31 and 55 g, respectively, at 12 weeks when compared to
control (20 g). Weight, BMI and % total body fat were significantly
reduced in FIB and HLT-FIB groups, with weight and BMI significantly
reduced in the HLT group compared with control at 12 weeks. HLT-FIB
and HLT groups had significant reductions in TAG and insulin
compared with control at 6 and 12 weeks, and in insulin compared
with the FIB group at 12 weeks. The HLT-FIB, HLT and FIB groups all
had significant reductions in total cholesterol and LDL-cholesterol
compared with control after 6 and 12 weeks. The present study
demonstrated that simply adding psyllium fibre supplementation to a
normal diet was sufficient to obtain beneficial effects in risk
factors. However, a high-fibre diet consisting of a psyllium
supplement plus fibre from a healthy diet provided the greatest
improvements in metabolic syndrome risk factors.
-
J Clin Gastroenterol. 2010
Sep;44 Suppl 1:S58-60.
The right fiber for the right disease: an update on the psyllium
seed husk and the metabolic syndrome.
Giacosa A,
Rondanelli M.
Department of Gastroenterology and Clinical Nutrition, Policlinico
di Monza, Monza, Italy.
attilio.giacosa@policlinicodimonza.it
Abstract
The metabolic syndrome (MS) is a clustering of hyperglycemia/insulin
resistance, dyslipidemia, overweight and hypertension. MS identifies
patients who are at high risk of developing atherosclerotic
cardiovascular disease (CVD) and type 2 diabetes (T2D). Based on
current data dietary fibre intake from whole foods or supplements
may lower blood pressure, may improve serum lipid levels, may reduce
indicators of inflammations,may lower serum glucose levels and
favour body weight loss. US Food and Drug Administration in 2006
authorized a health claim that psyllium husk, beta glucan in oats
and beta glucan in barley can reduce the risk of heart disease.
Solubility in water, viscosity, fermentability, and the kind and
amounts of protein and tocotrienols have been explored as possible
basis for this effect. In particular, many experimental and clinical
studies suggest that psyllium does lower serum and liver cholesterol
concentrations and may increase HDL-cholesterol levels-
Moreover,water soluble fibres, such as psyllium, moderate post
prandial glucose and insulin concentrations in non-insulin dependent
diabetic patients, if taken with meals and favour the reduction of
body weight and hypertension. Therefore, the favourable effect of
various fibres and particularly of psyllium, on body weight
reduction and satiety, on cholesterol and tryglycerides levels, on
fasting glycaemia and on blood pressure suggests a potential role of
these fibres in the treatment of MS.
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24/08/2010
Trasmettiamo a seguire l'abstract di un lavoro che ci è parso interessante e che contribuisce a sostenere l'efficacia profilattica della "fortificazione" della dieta, ancorchè sana e bilanciata, con fibra da integrazione alimentare.
La fibra di Psyllium insieme a Fitosteroli, Inulina e Cellulosa costituiscono i compounds nutrizionali di Lipidyum, oggi disponibile anche nel gradevolissimo gusto Frutti Rossi (contenente estratto di sambuco).
Un cordiale saluto,
Marco Garimberti
- Br J Nutr.
2010 Aug 23:1-10.
The effect
of a fibre supplement compared to a healthy diet on body
composition, lipids, glucose, insulin and other metabolic syndrome
risk factors in overweight and obese individuals.
Pal S, Khossousi A, Binns C, Dhaliwal S,
Ellis V.
School of Public
Health, Curtin Health Innovation Research Institute, ATN Centre for
Metabolic Fitness, Curtin University of Technology, GPO Box U1987,
Perth, WA, Australia 6485.
Abstract
Optimum levels and types of dietary fibre that provide the greatest beneficial effects on metabolic syndrome risk factors in overweight and obese individuals have yet to be determined in clinical trials. The present parallel design study compared the effects of fibre intake from a healthy diet v. a fibre supplement (psyllium) or a healthy diet plus fibre supplement on fasting lipids, glucose, insulin and body composition. Overweight/obese adults were randomised to either control (with placebo), fibre supplement (FIB), healthy eating plus placebo (HLT) or healthy eating plus fibre supplement (HLT-FIB). There was a significant increase in fibre intake in HLT-FIB, HLT and FIB groups up to 59, 31 and 55 g, respectively, at 12 weeks when compared to control (20 g). Weight, BMI and % total body fat were significantly reduced in FIB and HLT-FIB groups, with weight and BMI significantly reduced in the HLT group compared with control at 12 weeks. HLT-FIB and HLT groups had significant reductions in TAG and insulin compared with control at 6 and 12 weeks, and in insulin compared with the FIB group at 12 weeks. The HLT-FIB, HLT and FIB groups all had significant reductions in total cholesterol and LDL-cholesterol compared with control after 6 and 12 weeks. The present study demonstrated that simply adding psyllium fibre supplementation to a normal diet was sufficient to obtain beneficial effects in risk factors. However, a high-fibre diet consisting of a psyllium supplement plus fibre from a healthy diet provided the greatest improvements in metabolic syndrome risk factors.
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20/03/2010
Gentile Corrispondente,
cliccando su questo collegamento troverà il Poster relativo ad uno studio promosso spontaneamente dal Centro Universitario Dislipidemie presso l'Ospedale Niguarda di Milano riguardante l'efficacia ipocolesterolemizzante, ma anche favorente il calo ponderale, di Lipidyum.
E' una conferma interessante dell'efficacia dei 2 ingredienti attivi
combinati (Fitosteroli e fibra viscosa
da Psyllum) contenuti nel nostro formulato, efficacia superiore a
quella delle 2 sostanze prese separatamente: ciò dimostra una
complementarietà d'azione e nessuna interazione/depotenziamento
reciproco.
Marco Garimberti
-----
22/01/2010
Ci pregiamo trasmettere il link a significativa letteratura scientifica, che ribadisce il razionale all'utilizzo della fibra viscosa e dei fitosteroli nel controllo di condizioni di carattere metabolico ed intestinale.
L'interessante, recentissima review sulle fibre alimentari, appena pubblicata su Gastroenterology, integralmente scaricabile dal link a fondo mail, supporta indubbiamente la scelta del tipo e del dosaggio di fibra viscosa, che abbiamo prescelti per il nostro complemento Lipidyum.
Rircordiamo anche che Lipidyum é:
- più fibra: rispettivamente 4,3 g e 5,0 g di fibra
pro dose nel formato bustina o tavoletta;
- più di 1 fibra contiene oltre a Psyllium, Inulina
e Cellulosa, coinvolte nella maggior efficacia intestinale del
complemento;
- più della fibra contiene in aggiunta alla
fibra rispettivamente 0,9 g e 1,0 g di Fitosteroli non esterificati
pro dose nel formato bustina o tavoletta, per una più incisiva
azione ipocolesterolemizzante.
Costo: il Lipidyum si pone tra gli integratori di fibra alimentare
dal minor costo sul mercato; in detto costo é compreso anche quello
dei fitosteroli; un prodotto pertanto dalla convenienza
ineguagliata.
Per richiedere saggi di Lipidyum, rispondere alla presente,
segnalando variazioni d'indirizzo consegna merce, se intervenute e
numero di telefono portatile.
Marco Garimberti
-----
10/03/2009
Gentile Dottore,
é confermata l'azione favorevole degli Steroli Vegetali sul metabolismo lipidico nella Persona diabetica.
Ricordiamo che Lipidyum é basato su 2 fitosostanze, la Fibra Viscosa da psyllium e gli Steroli Vegetali non esterificati da pino, rispettivamente g 3,5 e g 0,8 pro dose, già raccomandate dall'Adult Treatment Panel III e dall'AHA per il controllo non farmacologico della colesterolemia LDL, diversamente da altre sostanze ad azione statinosimile e non, non ancora sufficientemente indagate sul piano clinico e farmacologico.
Un saluto, Garimberti Marco
-
Diabetes
Res Clin Pract. 2009 Feb 23.
The effect of plant sterols or stanols on lipid parameters in patients
with type 2 diabetes: A meta-analysis.
Baker
WL,
Baker
EL,
Coleman
CI.
The Evidence-Based Practice Center, Hartford Hospital, Hartford, CT,
United States.
We performed a meta-analysis of five randomized, placebo-controlled
trials to characterize the impact of plant sterols/stanols on plasma
lipids in patients with type 2 diabetes. Upon meta-analysis, plant
sterols/stanols significantly reduced total and LDL cholesterol, with a
trend towards improvement in HDL. No beneficial effect on triglycerides
was apparent.
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Gentile Dottore, Le inviamo 2 link ad altrettanti articoli, di Suo sicuro interesse, ricordandoLe che Lipidyum é mirato alla riduzione della colesterolemia LDL e si propone come complemento nutrizionale ad azione metabolico-digestiva tout court.
Restiamo disponibili all'invio di saggi gratuito del prodotto che, ricordiamo, non contiene aspartame, né tantomeno riso rosso fermentato (monacolina-lovastatina), berberina, policosanoli, ma unicamente Fitosteroli liberi e fibra viscosa da Psyllium in combinazione.
Un saluto,
Garimberti Marco
http://www.innovares.com/SITOITALIANO/prodotti/lipidyum/letteratura/association.pdf
http://www.innovares.com/SITOITALIANO/prodotti/lipidyum/letteratura/HDL%20cholesterol%20BMJ.pdf
-----
23/01/2009
Gentile Dottore,
riteniamo
sia un dato significativo quello evidenziato dallo studio sotto indicato.
La colesterolemia totale ed LDL può essere controllata senza
necessariamente ricorrere alla terapia farmacologica e con l'aiuto di
sostanze di comprovata NON TOSSICITA', associate ad
una dieta adeguata e ad un miglioramento nello stile di vita.
Nel caso desideri saggi gratuiti del nostro Lipidyum (fibra viscosa da Psyllium + Fitosteroli non esterificati + fibra solubile da Inulina), risponda alla presente, precisando luogo di destinazione se diverso da quello consueto.
Un saluto,
Garimberti Marco
ps: ricordiamo che Lipidyum é privo di aspartame, acesulfame, saccarina sodica, ciclamati, quali agenti edulcoranti ed é privo di policosanoli, riso rosso fermentato, berberina.
- Lipids.
2009 Jan 15.
Phytosterol Intake and Dietary Fat Reduction are Independent and
Additive in their Ability to Reduce Plasma LDL Cholesterol.
Chen SC, Judd JT, Kramer M, Meijer GW, Clevidence BA, Baer DJ.
Food Components and Health Laboratory, Beltsville Human Nutrition Research
Center, USDA, ARS, Beltsville, MD, USA.
We studied the interrelationship of diet and plant sterols (PS) on plasma
lipids, lipoproteins and carotenoids. Mildly hypercholesterolemic men (n =
13) and postmenopausal women (n = 9) underwent four randomized, crossover,
double-blind, controlled feeding periods of 23 days each. The design
consisted of two levels of PS (0 and 3.3 g/day) and two background diets
having fat content either typical of the American diet (total and saturated
fat at 33.5 and 13.2% of energy, respectively), or a Step 1 type of diet
(total and saturated fat at 26.4 and 7.7% of energy, respectively). Plasma
total cholesterol (TC), high density lipoprotein (HDL) cholesterol, low
density lipoprotein (LDL) cholesterol, Apo A1 and Apo B were 4.3, 5.3, 4.5,
2.8 and 2.5% lower, respectively (P </= 0.0001; <0.0001, 0.0016,
0.0006, and 0.0069), with the Step 1 diet than with the typical American
diet. Diet had no effect on TC/HDL cholesterol (P = 0.1062). Plant sterol
intake lowered TC, LDL cholesterol, and Apo B by 9.0, 12.4 and 6.1% and TC/HDLC
by 9.6% (P </= 0.0001 for all), respectively, without affecting HDL
cholesterol and Apo A1 (P = 0.2831 and 0.732). The PS effect in lowering
plasma TC and LDL cholesterol was independent of and additive to the effect
due to dietary fat reduction. Responses of plasma carotenoids to PS intake
were consistent with the literature.
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03/12/2008
Gentile Dottore esperto in Nutrizione,
sono sempre più
numerosi i nuovi "botanicals", che promettono una significativa efficacia
ipocolesterolemizzante associata a diversi (?) meccanismi d'azione rispetto
alle molecole "tradizionali" sintetiche, tuttavia... non nuocere ed una
corretta valutazione dei costi-benefici resta la prima regola.
In altre parole la NON tossicità a lungo termine di una sostanza da assumere cronicamente deve essere ben documentata.
Innovares si muove nell'ambito di molecole di documentata sicurezza, di molecole considerabili per loro stessa natura più vicine agli alimenti piuttosto che ai farmaci, molecole che di norma siano assunte con la normale alimentazione a dosaggi più prossimi ai grammi piuttosto che ai milligrammi... molecole comunque consigliate dalle linee guida internazionali, come quelle contenute in Lipidyum.
Un cordiale saluto,
Garimberti Marco
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Mechanisms
of Berberine (Natural Yellow 18)-Induced Mitochondrial Dysfunction:
Interaction with the Adenine NucleotideTranslocator
Cláudia
V. Pereira, Nuno G. Machado and Paulo J. Oliveira1
Center
of Neurosciences and Cell Biology, Department of
Zoology, University of Coimbra, 3004-517 Coimbra, Portugal1
To whom correspondence should be addressed at Center of Neurosciences and
Cell Biology, Department of Zoology, University of Coimbra, 3004-517 Coimbra,
Portugal. Fax: +351-239855789.
E-mail:pauloliv@ci.uc.pt
Received
May 13, 2008;
accepted
June 26, 2008
Berberine
[Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo (5,6-a) quinolizinium] is an alkaloid present in plants of the Berberidaceae family and used in traditional Chinese and North American
medicine. We have previously demonstrated that berberine causes mitochondrial
depolarization and fragmentation, with simultaneous increase
in oxidative stress. We also demonstrated that berberine
causes an inhibition of mitochondrial respiration and a
decrease on calcium loading capacity through induction of the
mitochondrial permeability transition (MPT). The objective of
the present work is to investigate a common target for both induction
of the MPT and inhibition of respiration. The hypothesis is
that berberine induces the MPT through interacting with the adenine
nucleotide translocator (ANT). By measuring induction of the
MPT through increased mitochondrial swelling, membrane depolarization
and loss of calcium retention, we observed that the effects of
berberine were not inhibited by bongkrekic acid although
adenosine diphosphate (ADP)/oligomycin completely prevented the
MPT. Also, we observed that berberine increased the depolarization effect
of oleic acid on liver mitochondria. The initial depolarization observed
when berberine is added to mitochondria was not affected by ANT
inhibitors. Taken together, we propose that berberine acts on the
ANT, altering the binding of the protein to bongkrekic acid but
not to cyclosporin A or ADP. It is also clear that the membrane
potential is required for berberine effects, most likely for
allowing for its mitochondrial accumulation. Mitochondrial effects
of berberine can be relevant not only for its proposed antitumor
activity but also for the assessment of its organ toxicity,
depending on factors such as tissue accumulation ordelivery.
Key
Words: Berberine; toxicology; transition pore; mitochondria;
adenine nucleotide translocator
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15/10/2008
Gentili Corrispondenti,
sono tutti favorevoli, sia in punto efficacia sia in punto sicurezza, i recenti studi pubblicati a tema steroli vegetali (fitosteroli); ribadita é l'utilità della fibra viscosa nella prevenzione della malattia cardiovascolare, efficace come é noto anche nel migliorare il transito intestinale.
Vi ricordiamo che la maneggevolezza di Lipidyum é massima, NON contenendo monacolina k (lovastatina), berberina o altre sostanze non ancora indagate in merito alla loro tossicità cronica e alla loro possibile interazione/potenziamento con le statine sintetiche.
Lipidyum é estremamente maneggevole, in quanto contiene unicamente fitosteroli non esterificati e fibra viscosa da psyllium.
Un valido strumento nelle mani del Nutrizionista.
E' possibile richiedere saggi gratuiti del prodotto semplicemente rispondendo alla pesente.
Saluti, Garimberti
@ Retelny VS, Neuendorf A, Roth JL.
Nutrition Protocols for the Prevention of Cardiovascular Disease.
Nutr Clin Pract. 2008 Oct;23(5):468-476.
@ de Jong A, Plat J, Lütjohann D, Mensink RP.
Effects of long-term plant sterol or stanol ester consumption on lipid and lipoprotein metabolism in subjects on statin treatment.
Br J Nutr. 2008 Nov;100(5):937-41.
@ Rudkowska I, AbuMweis SS, Nicolle C, Jones PJ.
Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal.
J Am Coll Nutr. 2008 Oct;27(5):588-95.
@ Reynolds TM, Mardani A, Twomey PJ, Wierzbickid AS.
Targeted versus global approaches to the management of hypercholesterolaemia.
J
R Soc Health. 2008 Sep;128(5):248-54
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14/06/2008
Lipidyum, quale fattore di counseling alimentare finalizzato alla riduzione della colesterolemia LDL, é opportuno sia assunto, in dose plurima giornaliera, come attesta anche il lavoro sotto riportato.
Da non trascurare l'effetto saziante dato dall'assunzione di Lipidyum ai pasti principali.
Grazie per l'ascolto e buona Domenica.
Garimberti
European
Journal of Clinical Nutrition advance online publication, 4
June 2008; doi:10.1038/ejcn.2008.36.
Plant sterol consumption frequency affects plasma lipid
levels and cholesterol kinetics in humans.
Abumweis
SS, Vanstone CA, Lichtenstein
AH, Jones
PJ.
1School of Dietetics and Human Nutrition, McGill University,
Ste-Anne-de-Bellevue, Montréal, Quebec, Canada.
Background/Objectives:To
compare the efficacy of single versus multiple doses of plant
sterols on circulating lipid level and cholesterol
trafficking.Subjects/Methods:A randomized, placebo-controlled,
three-phase (6 days/phase) crossover, supervised feeding trial
was conducted in 19 subjects. Subjects were provided (i)
control margarine with each meal; (ii) 1.8 g/day plant sterols
in margarine with breakfast (single-BF) and control margarine
with lunch and supper or (iii) 1.8 g/day plant sterols in
margarine divided equally at each of the three daily meals (three
times per day).Results:Relative to control, end point plasma
low-density lipoprotein (LDL) cholesterol concentrations were
lower (P<0.05) after consuming plant sterols three times
per day but were not different when consumed once per day
(3.43+/-0.62, 3.22+/-0.58 and 3.30+/-0.65 mmol/l, control,
three times per day and single-BF, respectively). Relative to
the control, end point LDL level was 0.21+/-0.27 mmol/l (6%)
lower (P<0.05) at the end of the three times per day phase.
Cholesterol fractional synthesis rate was highest (P<0.05)
after the three times per day phase (0.0827+/-0.0278,
0.0834+/-0.0245 and 0.0913+/-0.0221 pool/day, control,
single-BF and three times per day, respectively).
Cholesterol-absorption efficiency decreased (P<0.05) by 36
and 39% after the three times per day and single-BF phase,
respectively, relative to control. Conclusions: Present data
indicate that to obtain optimal cholesterol-lowering impact,
plant sterols should be consumed as smaller doses given more
often, rather than one large dose.
^ Inizio